Located within the iconic Mandalay Bay Resort and Casino, House of Blues Las Vegas is a premier entertainment venue known for its vibrant atmosphere, eclectic music lineup, and Southern-inspired decor. This venue offers a unique blend of live music, dining, and events, making it a top choice for both tourists and locals. With a spacious concert hall, intimate settings, and state-of-the-art sound and lighting, it hosts a wide range of performances from rock bands to blues legends and everything in between.